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通过抑制亲环蛋白 D 的假缺氧性 HIF1α 稳定促进黑色素 ...
韩国蔚山科学技术院(Ulsan National Institutes of Science and Technology, UNIST)的研究人员针对这一问题,开展了关于黑色素瘤中 HIF1α 稳定机制的研究,揭示了线粒体亲环蛋白 D(CypD,调控线粒体通透性转换孔的关键蛋白)抑制通过假缺氧状态稳定 HIF1α 并促进转移的分子机制,为开发抗转移疗法提供了新靶 ...
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