Objective To report the performance of clinical practice guidelines (CPG) in the diagnosis of serious/invasive bacterial infections (SBI/IBI) in infants presenting with a fever to emergency care in ...

Objective To report the diagnostic test accuracy of dipstick urinalysis for the detection of urinary tract infections (UTIs) in febrile infants aged 90 days or less attending the emergency department ...

Objective To study the impact of body mass index (BMI) SD score (SDS) improvement through lifestyle modification on metabolic risk and body composition over 12 months. Design Prospective cohort study.

> Optimism is a good characteristic, but if carried to an excess, it becomes foolishness. Theodore Roosevelt1 We would define an innovative therapy as any newly introduced treatment, or a new ...

This series of systematic reviews was commissioned by WHO in July 2022 to inform their guideline review process. The aim was to identify the current evidence for developing WHO guidelines for the ...

Unaccompanied children (also called unaccompanied minors) are children who have been separated from both parents and other relatives and are not being cared for by an adult who, by law or custom, is ...

Rationale Studies suggest that increased breastfeeding rates can provide substantial financial savings, but the scale of such savings in the UK is not known. Objective To calculate potential cost ...

Paediatric dose cannot be scaled down directly from an adult using weight (eg, mg/kg). This results in a dose too small in infants and children because elimination does not change in direct proportion ...

For anyone, undergoing surgery is stressful. For children on the autism spectrum, it can be even more traumatic. Sensory differences are present in the majority of children on the autism spectrum,1 ...

Oral health is part of general health and well-being and contributes to the development of a healthy child. The most common oral disease affecting young children is dental caries (figure 1), which is ...

The hierarchy of evidence in assessing the effectiveness of interventions or treatments is explained, and the gold standard for evaluating the effectiveness of interventions, the randomised controlled ...

Objective To investigate a reported rise in the emergency hospital admission of children in England for conditions usually managed in the community. Setting and design Population-based study of ...