Oregon Health & Science University said the couple’s donation would be the largest single gift to a higher-learning institution in the United States.

The Knight Foundation said the gift that will be used to shift the scientific approach to cancer treatment, research and patient care outcomes.

Nike co-founder Phil Knight and his wife Penny Knight have pledged to donate $2 billion to Oregon Health & Science University’s Knight Cancer Institute, the school announced Thursday, describing it as the largest single gift to a U.