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Nat Cell Biol:科学家揭秘细胞“脚手架”指挥伤口愈合背后的分子机制
这项研究中,研究人员设计了两类PDMS模具(锯齿矩形和花朵形)并精确控制上皮单层边缘曲率。通过超分辨成像(SoRa技术)发现,凸缘处内质网形成管状网络,与垂直于边缘的微管和黏着斑共定位;而凹缘处则转化为片状结构,平行于收缩性肌动蛋白束。定量分析显示, ...
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