The calling program thinks tat it's passing a two-dimensional matrix–the data array and its dimensions. The subroutine sees only a linear array and uses Equation 8 to index into it.

High-throughput tissue arrays allow for evaluation of in vitro cellular responses and correlation to matrix composition.

The Annals of Statistics, Vol. 38, No. 2 (April 2010), pp. 1094-1121 (28 pages) We consider dimension reduction for regression or classification in which the predictors are matrix- or array-valued.