Although randomization has been used in phase I trials to simultaneously test different doses of experimental anticancer agents (for example, pembrolizumab 65 (NCT01295827)), to our knowledge, it ...

Randomized clinical trials serve as the standard for clinical research and have contributed immensely to advances in patient care. Nevertheless, several shortcomings of randomized clinical trials ...

We provide an explicit asymptotic method to evaluate the performance of different response-adaptive randomization procedures in clinical trials with continuous outcomes. We use this method to ...

Clinical trials are well-controlled and designed experiments that aim to prove that an Investigational Medicinal Product (IMP) is effective.

Both randomized controlled trials and real-world evidence can help define a treatment’s absolute value and its value relative to alternative interventions, but they do so in different ways.

PurposeThe majority of randomized oncology trials are two-arm studies that test the efficacy of new therapies against a standard of care, thereby assigning a large proportion of patients to ...

Among abstracts that were eventually published in NEJM or other top medical journals with the highest impact factors, 72.1% ...

The National Cancer Institute (NCI) and the Patient-Centered Outcomes Research Institute (PCORI) have made major investments to fund seven randomized clinical trials evaluating the benefits and harms ...