Randomized clinical trials serve as the standard for clinical research and have contributed immensely to advances in patient care. Nevertheless, several shortcomings of randomized clinical trials ...

We provide an explicit asymptotic method to evaluate the performance of different response-adaptive randomization procedures in clinical trials with continuous outcomes. We use this method to ...

PurposeThe majority of randomized oncology trials are two-arm studies that test the efficacy of new therapies against a standard of care, thereby assigning a large proportion of patients to ...

Future progress in improving cancer therapy can be expedited by better prioritization of new treatments for phase III evaluation. Historically, phase II trials have been key components in the ...

Both randomized controlled trials and real-world evidence can help define a treatment’s absolute value and its value relative to alternative interventions, but they do so in different ways.

Clinical trials are well-controlled and designed experiments that aim to prove that an Investigational Medicinal Product (IMP) is effective.